Some Immunochemical Properties of Penicillenic Acid

The Preparation and Some Properties of Penicillenic Acid Derivatives Relevant to Penicillin Hypersensitivity

A number of penicillenate and penicilloyl derivatives potentially useful in the study of penicillin hypersensitivity have been prepared and some of their properties described.

Some Immunochemical Properties of Penicillenic Acid an Antigenic Determinant D~-~ved ~ro~ Penicillin*

Penicillin hypersensitivity in man is recognized as a clinical problem of considerable magnitude (1). Although this problem has received much attention, the antigenic determinant(s) responsible are not known. The identification of the determinant(s) is important for several reasons. First, it could permit the preparation of reliable reagents for identifying hypersensitive individuals. Second, i...

Hypersensitivity to Penicillenic Acid Derivatives in Human Beings with Penicillin Allergy

Multifunctional derivatives of penicillenic acid are effective elicitors of wheal-and-erythema skin responses in humans allergic to penicillin. Of the effective derivatives, penicilloyl-polylysines are particularly attractive as skin test reagents because they appear to be incapable of inducing antibody formation. The skin responses are specifically inhibitable in most instances by homologous u...

Immunologic Cross-reactivities of Three Diverse Penicillins.

RECENT investigations have demonstrated the importance of the benzylpenicilloyl group as an antigenic determinant in benzylpenicillin (PG) hypersensitivity (Levine and Ovary, 1961) (Fig. 1). It has been suggested that this antigen is formed by the conjugation to protein of the highly reactive intermediate, benzylpenicillenic acid (Fig. 1, B). A number of conventional penicillins derived from 6-...

Effect of Humic Acid on Some Morphological and Biochemical Properties and Mineral Nutrients Concentration of Aloe Vera under Salinity Stress